innovationMADE BY ZEISS

实现非黑色素瘤皮肤癌的靶向照射。蔡司 IORT解决方案

innovationMADE BY ZEISS

非-黑色素瘤皮肤癌

治疗

电子近距离放疗

蔡司INTRABEAM^® 的多功能性也在皮肤癌方面展现得淋漓尽致。特别在非黑色素瘤皮肤癌的治疗中，千伏级放射治疗是一种重要的治疗选择，其也适用于有较高手术风险的患者。¹ 在一项前瞻性研究中，对于非黑色素瘤皮肤癌的治疗，术中放疗与常规传统放疗技术一样有效。² 蔡司INTRABEAM^® 众所周知的优点– 靶向照射、低屏蔽要求、以及成本效益-也适用于非黑色素瘤皮肤癌的治疗。³

治疗步骤

第1步 评估肿瘤大小、深度和准确位置，选择正确的位置标记。

第2步 将位置标记固定在正确的位置。

第3步 放置施用器置于位置标记中。

第4步 控制并设置施用器的最终位置。

第5步 执行近距离放疗。

第6步 治疗后皮肤愈合。
文献
文献一览
1。脑瘤

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2。乳腺癌

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Welzel, G., Blank, E., Kraus-Tiefenbacher, U., Keller, A., Vorodi, F., Herskind, C., … Wenz, F. K. (2008).乳腺癌保乳手术和外放疗(EBRT)期间IORT之间的间隔对晚期毒性的影响。Journal of Clinical Oncology, 26, 630.

Welzel, G., Boch, A., Sperk, E., Hofmann, F., Kraus-Tiefenbacher, U., Gerhardt, A., … Wenz, F. (2013).Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomised phase III trial TARGIT-A. Radiation Oncology, 8(1), 9.

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Williams, N. R., Pigott, K. H., Brew-Graves, C., Keshtgar, M. R. S. (2014).乳腺癌术中放疗。Gland Surgery, 3(2), 109–119.
3。胃肠道肿瘤

Algur, E., Mahadevan, A., Deibel, C. (2005).间质光子放射治疗系统治疗复发和局部晚期直肠癌：24例回顾性分析。ASCO Gastrointestinal Cancers Symposium, Jan 27–29, Hollywood, Florida, USA, Abstract No 208.

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Haddock, M. G. (2016).局部晚期和复发性直肠癌的照射。Seminars in Radiation Oncology, 26(3), 226–235.

Haddock, M. G. (2017).术中放疗治疗结直肠癌的临床观察。Radiation Oncology, 12(1), 11.

Lyadov, K., Krymskiy, V., Markin, A., Krymskiy, A. (2008).胃癌的综合治疗中使用intra beam系统的术中辐射安全性评价。Poster Abstract Presented at the ISIORT Meeting.

Lyadov, K., Yu, S., Krymskiy, V., Krymskiy, A. (2008).由于使用INTRA BEAM系统进行术中接触放射治疗导致的结直肠癌视频辅助手术的治疗改进。ISIORT.

National Comprehensive Cancer Network® - Guidelines for Colon & Rectal Cancer, 2016

Polkowski, W. P., Skórzewska, M. (2014).低能量光子术中放疗在直肠癌复发中的应用。(M. Keshtgar, K. Pigott, & F. Wenz, Eds.), Targeted Intraoperative Radiotherapy in Oncology.柏林, 海德堡:Springer Berlin Heidelberg.

Potemin, S., Uvarov, I., Vasilenko, I. (2015).局部晚期复发直肠癌术中放疗68例回顾性分析。Transl Cancer Res, 4(2), 189–195.

Skórzewska, M., Mielko, J., Kurylcio, A., Romanek, J., Polkowski, W. P. (2016).低能量光子术中放疗治疗复发性结直肠癌：单中心回顾性研究。Współczesna Onkologia, 20(1), 52–57.

Susko, M., Lee, J., Salama, J., Thomas, S., Uronis, H., Hsu, D., … Palta, M. (2016).再照射在局部复发、非转移性直肠癌中的应用。外科肿瘤学纪事。
4。头 & 颈部肿瘤

Abo-Madyan, Y., Gößler, U., Vent, J., Nwankwo, C., Schneider, F., Hörmann, K., Wenz, F. (2013).使用移动50kV微型加速器术中放疗复发性头 & 颈部鳞状细胞癌。DEGRO 2013, Poster.

Chen, A. M., Bucci, M. K., Singer, M. I., Garcia, J., Kaplan, M. J., Chan, A. S., Phillips, T. L. (2007).术中放疗治疗复发性头颈部肿瘤：UCSF的经验。International Journal of Radiation Oncology*Biology*Physics, 67(1), 122–129.

De Felice, F., Musio, D., Tombolini, V. (2016).复发性头颈癌的术中放疗(IORT)。Oral Oncology, 55(March), e1.

Kyrgias, G., Hajiioannou, J., Tolia, M., Kouloulias, V., Lachanas, V., Skoulakis, C., … Bizakis, I. (2016).头颈癌的术中放疗(IORT)：系统回顾。Medicine, 95(50), e5035.

Münter, M. W., Köppen, U., Ramuscak, A., Sittel, C., Wegner, N. (2015).术中放疗(IORT)在头部和颈部癌症方面的治疗。Transl Cancer Res, 4(2), 178–181.

Roopashri, G., Baig, M. (2013).头颈部恶性肿瘤放射治疗的研究进展。Journal of International Oral Health, 5(6), 119–23.

Rutkowski, T., Wygoda, A., Hutnik, M., Składowski, K., Wydmański, J., Maciejewski, A., … Maciejewski, B. (2010).使用低能量光子进行术中放疗(IORT)作为有术后放疗适应症的早期口腔癌患者的推量治疗：治疗便利性和初步结果。Strahlentherapie Und Onkologie, 186(9), 496–501.
5。非-黑色素瘤皮肤癌

Amini, S., Viera, M. H., Valins, W., Berman, B. (2010).非黑素瘤皮肤癌治疗的非手术治疗的创新。The Journal of Clinical and Aesthetic Dermatology, 3(6), 20–34.

Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., … Munro, A. (2007).乳腺局部照射时极低能量X射线皮肤剂量的测量。Clinical Oncology, 19(3), S23.

Bhatnagar, A., Loper, A. (2010).电子近距离放射治疗非黑色素瘤皮肤癌的初步经验。Radiation Oncology (London, England), 5, 87.

Chan, S., Dhadda, A.S.(2007) Swindell, R., Single fraction radiotherapy for small superficial carcinoma of the skin.Clin Oncol (R Coll Radiol), 19(4), 256-9.

Cognetta, A. B., Howard, B. M., Heaton, H. P., Stoddard, E. R., Hong, H. G., Green, W. H. (2012).浅表X线在基底细胞癌和鳞状细胞癌治疗中的应用：选择患者中可行的选择。Journal of the American Academy of Dermatology, 67(6), 1235–41.

Bodner, W. R., Hilaris, B. S., Alagheband, M., Safai, B., Mastoras, C. A., Saraf, S. (2003).浅表非黑色素瘤皮肤癌治疗中的的低能量X -射线的使用。Cancer Investigation, 21(3), 355–362.

Ducassou, A. (2015).INTRABEAM在 IUCT Oncopole Toulouse的皮肤治疗初体验。In ESTRO proceeding.

Ermertcan, A. T., Hellings, P. W., Cingi, C. (2012).头部和颈部的非黑素瘤皮肤癌的非手术治疗。Facial Plastic Surgery Clinics of North America, 20(4), 445–54.

Goubert, M., Parent, L. (2015).INTRABEAM®小型加速器平板和表面施用器关于皮肤病学的剂量学特性。Physica Medica, 31(3), 224–232.

Jankarashvili, N., Topeshashvili, M. (2015).用 intrabeam治疗皮肤癌。9th ZEISS INTRABEAM User Meeting.

Levell, N. J., Igali, L., Wright, K. A., Greenberg, D. C. (2013).英国基底细胞癌流行病学：室内象。Clinical and Experimental Dermatology, 38(4), 367–9.

Nguyen, T. H., Ho, D. Q.-D. (2002).非黑色素瘤皮肤癌。Current Treatment Options in Oncology, 3(3), 193–203.

Perkins, J. L., Liu, Y., Mitby, P. A., Neglia, J. P., Hammond, S., Stovall, M., … Mertens, A. C. (2005).儿童和青少年癌症幸存者的非黑素瘤皮肤癌：一项儿童癌症幸存者的研究报告。Journal of Clinical Oncology, 23(16), 3733–41.

Tward, J.D., Anker, C, J,.Gaffney, D.K., Bowen, G. .(2012)。放射治疗与皮肤癌。Modern Practices in Radiation Therapy, 207–246.
6。脊柱转移瘤

Berenson, J., Pflugmacher, R., ..., Jarzem, P. (2011) Cancer Patient Fracture Evaluation (CAFE) lnvestigators.球囊扩张椎体后凸成形术与非手术骨折治疗癌症患者疼痛性椎体压缩骨折的多中心、随机对照试验。Lancet Oncology, 12(3), 225-35.

Bludau, F., Obertacke, U., Schmidt, R. (2012).Kypho IORT后的首次中期结果。European Spine Journal, 21(11), 2332.

Bludau, F. (2014).脊柱-IORT：脊柱转移瘤术中放疗：九个月临床结果。The Spine Journal, 14(11), S163

Bludau, F., Reis, T., Schneider, F., Clausen, S., Wenz, F., Obertacke, U. (2015).椎体后凸成形术结合术中放疗 (Kypho-IORT)。Der Radiologe, 55(10), 859–867.

Kayser, R., Ender, S. A., Asse, E., Wilhelm, E., Adler, F., Schmidt, R., … Bludau, F. (2013).椎体后凸成形术结合术中放疗。Der Orthopäde, 42(9), 765–771.

Miglierini, P., Dam-Hieu, P., Key, S. (2014).Kypho-IORT:首个法国治疗。Translational Cancer Research, 3(1).

Reis, T., Schneider, F., Hermann, B., Bohrer, M., Schmitt, R., Obertacke, U., Wenz, F. (2010).脊柱-IORT：椎体后凸成形术中放疗治疗脊柱转移瘤。International Journal of Radiation Oncology Biology Physics, 78(3), S581–S582.

Reis, T., Schneider, F., Welzel, G., Schmidt, R., Bludau, F., Obertacke, U., Wenz, F. (2012).椎体转移瘤椎体后凸成形术(Kypho IORT)期间的术中放疗：首批临床结果。Tumori, 98(4), 434–40.

Reis, T., Sperk, E., Schneider, F., Schmidt, R., Obertacke, U., Wenz, F. (2012).脊柱转移瘤的Kypho-IORT: 病例研究。Hospital Oncology & Haematology Europe, Campden Publishing Ltd, Apr, 21-24.

Schmidt, R., Obertacke, U., Wenz, F., Reis, T., Schneider, F. (2010).一项新的关于脊柱转移瘤微创术中放疗结合球囊扩张椎体后凸成形术(Kypho IORT)的临床可行性。European Spine Journal, 19(11), 2049.

Schmidt, R., Wenz, F., Reis, T., Janik, K., Bludau, F., Obertacke, U. (2012).椎体后凸成形术和术中放疗，脊柱转移瘤椎体后凸成形术和术中辐射相组合：一种新方法的技术可行性。International Orthopaedics, 36(6), 1255–1260.

Schneider, F., Greineck, F., Clausen, S., Mai, S., Obertacke, U., Reis, T., Wenz, F. (2011).脊柱转移瘤椎体后凸成形术 (Kypho-IORT)期间术中放疗新方法的建立。International Journal of Radiation Oncology*Biology*Physics, 81(4), 1114–1119.

Wenz, F., Schneider, F., Neumaier, C., Kraus-Tiefenbacher, U., Reis, T., Schmidt, R., Obertacke, U. (2010).Kypho-IORT – 脊柱转移瘤椎体后凸成形术的术中放疗的新方法。Radiation Oncology, 5(1), 11.
7。医学物理学

Armoogum, K. S., Parry, J. M., Souliman, S. K., Sutton, D. G., Mackay, C. D. (2007).术中放疗设备功能比对——光子放射治疗系统。Radiation Oncology, 2(1), 11.

Eaton, D. J., Duck, S. (2010).术中X射线装置的剂量测量。Physics in Medicine and Biology, 55(12), N359–N369.

Eaton, D. J., Gonzalez, R., Duck, S., Keshtgar, M. (2011).术中X射线装置的辐射保护。The British Journal of Radiology, 84(1007), 1034–1039.

Eaton, D. J., Best, B., Brew-Graves, C., Duck, S., Ghaus, T., Gonzalez, R., … Keshtgar, M. R. S. (2012).乳腺癌的单组术中靶向放疗(TARGIT)的体内剂量。International Journal of Radiation Oncology*Biology*Physics, 82(5), e819–e824.

Eaton, D. J. (2012).术中X射线装置的质量保证和独立剂量测定。Medical Physics, 39(11), 6908.

Ebert, M. A., Asad, A. H., Siddiqui, S. A. (2009).对于非常低能量X射线剂量的辐射变色薄膜的适宜性。Journal of Applied Clinical Medical Physics / American College of Medical Physics, 10(4), 2957.

Cardoso, M. J., Cardoso, J. S., Oliveira, H. P., Gouveia, P. (2016).乳腺癌保守治疗。美容效果– BCCT.core – 对乳腺癌保守治疗的美学效果客观评价软件：叙事评论。Computer Methods and Programs in Biomedicine, 126, 154–159.

Chiavassa, S., Buge, F., Hervé, C., Delpon, G., Rigaud, J., Lisbona, A., Supiot, S. (2015).盆腔中低能量光子术中放疗剂量计算的不均匀性影响的蒙特卡洛评估。Physica Medica, 31(8), 956–962.

Darby, S. C., Ewertz, M., McGale, P., Bennet, A. M., Blom-Goldman, U., Brønnum, D., … Hall, P. (2013).女性乳腺癌放疗后缺血性心脏病的风险。New England Journal of Medicine, 368(11), 987–998.

Eaton, D. J., Earner, B., Faulkner, P., Dancer, N. (2013).术中放疗的国家剂量学审核。The British Journal of Radiology, 86(1032), 20130447.

Emami, B., Woloschak, G., Small Jr, W. (2015).超越线性二次模型 ：术中放疗和正常组织耐受性。Transl Cancer Res, 4(2), 140–147.

Goubert, M., Parent, L. (2015).INTRABEAM^®小型加速器平板和表面施用器关于皮肤病学的剂量学特性。Physica Medica, 31(3), 224–232.

Härtl, P. M., Dobler, B., Kölbl, O., Treutwein, M. (2009).Intrabeam^®(蔡司)放射进行术中治疗的实用剂量测定和密度。Zeitschrift Für Medizinische Physik, 19(4), 288–293.

Hill, R., Healy, B., Holloway, L., Kuncic, Z., Thwaites, D., Baldock, C. (2014).千伏X射线束剂量学研究进展。Physics in Medicine and Biology, 59(6), R183–R231.

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013).乳腺癌靶向放疗后美容效果的客观评价：随机对照试验结果。Breast Cancer Research and Treatment, 140(3), 519–525.

Xu, Y., & Lam, S. (2013).蔡司IntraBeam平板和表面施用器的剂量学特点。Medical Physics, 40(6), 284–284.

Lam, S. C. P., Xu, Y., West, M. (2016).低-KVIORT向前突出施用器的屏蔽效果。EC Cancer, 2(1), 64–75.

Muralidhar, K. R., Rout, B., Mallikarjuna, A., Poornima, A., Murthy, P. N. (2014).Intrabeam术中放疗设备的试行和质量保证。International Journal of Cancer Therapy and Oncology, 2(4), 20415.

Nwankwo, O., Clausen, S., Schneider, F., Wenz, F. (2013).一种高压放射治疗设备的虚拟源模型。Physics in Medicine and Biology, 58(7), 2363–2375.

Preuss, J., Lester, L., Saunders, C. (2012).BCCT.core – 计算机程序可以用于乳房重建手术后的审美结果的评估吗？The Breast, 21(4), 597–600.

Price, C., Pederson, A., Frazier, C., Duttenhaver, J. (2013).乳腺癌术中放疗的光刺激剂量计的体内剂量和RTQA2辐射变色薄膜。Medical Physics, 40(9), 91716.

Schneider, F., Clausen, S., Jahnke, A., Steil, V., Bludau, F., Sütterlin, M., … Wenz, F. (2014).相比于C型臂透视技术的术中X-射线源的辐射防护。Zeitschrift Fur Medizinische Physik, 24(3), 243–251.

Schneider, F., Clausen, S., Thölking, J., Wenz, F., Abo-Madyan, Y. (2014).使用50kV X射线源的浅表性术中放疗的新方法(IORT)：技术和病例报告。Journal of Applied Clinical Medical Physics / American College of Medical Physics, 15(1), 4502.

Sethi, A., Chinsky, B., Gros, S., Diak, A. (2015).低kV术中放疗 (IORT)的组织不均匀性校正。Translational Cancer Research, 4(2), 182–188.

Steenbeke, F., Gevaert, T., Tournel, K., Engels, B., Verellen, D., Storme, G., Ridder, M. D. (2015).使用EBT3 GafChromic膜的50-kV放疗单位的质量保证：可行性研究。Technology in Cancer Research & Treatment, 15(1), 163–70.

Watson, P. G. F., Seuntjens, J. (2016).技术说明:显M和N-壳原子跃迁对低能X射线源的影响。Medical Physics, 43(4), 1760–1763.

Wuu, C.-S., Sheu, R.-D., Chen, J. (2015).在不同深度乳腺癌术中放疗的50 kV X射线的微剂量学特性。Radiation Protection Dosimetry, 166(1–4), 343–6.
8。放射生物学

Belletti, B., Vaidya, J. S., D’Andrea, S., Entschladen, F., Roncadin, M., Lovat, F., … Massarut, S. (2008).靶向术中放疗削弱了乳腺癌细胞增殖刺激和手术创伤造成的侵袭。Clinical Cancer Research, 14(5), 1325–1332.

Fabris, L., Berton, S., Citron, F., D’Andrea, S., Segatto, I., Nicoloso, M. S., … Belletti, B. (2016).放疗引起的miR-223通过靶向表皮生长因子通路防止乳腺癌复发。Oncogene, (February 2016), 1–13.

Herskind, C., Griebel, J., Kraus-Tiefenbacher, U., Wenz, F. (2008).使用低能量X射线术中放疗的新靶体积概念——等价球体。International Journal of Radiation Oncology*Biology*Physics, 72(5), 1575–1581.

Herskind, C., Ma, L., Liu, Q., Zhang, B., Schneider, F., Veldwijk, M. R., & Wenz, F. (2017).高剂量的IORT生物学：RBE, 5 R, 和其他生物方面。Radiation Oncology (London, England), 12(1), 24.

Herskind, C., Schalla, S., Hahn, E. W., Höver, K.-H., ..., Wenz, F. (2006)."旷日持久的适形放疗中，不同空间位置细胞恢复和RBE的不同剂量率的影响。"Radiation protection dosimetry, 122 (1-4), 498-505.

Herskind, C., Wenz, F. (2010).大分割加速部分乳腺照射(APBI)和50 kV X射线的单剂量术中放疗(IORT)的放射生物学的比较。Strahlentherapie Und Onkologie, 186(8), 444–451.

Herskind, C., Wenz, F. (2014).低能量X射线术中瘤床照射( LEX-IORT )的放射生物学方面。Transl Cancer Res, 3(1), 3–17.

Liu, Q., Schneider, F., Ma, L., Wenz, F., Herskind, C. (2013).术中瘤床照射模拟中测量的50kV X射线的相对生物效能(RBE)。International Journal of Radiation Oncology*Biology*Physics, 85(4), 1127–1133.

Minafra, L., & Bravatà, V. (2014).IORT治疗的细胞和分子反应。Translational Cancer Research, 3(1), 32–47.
Sologuren, I., Rodríguez-gallego, C., & Lara, P. C. (2014).高剂量放射治疗免疫作用：电离辐射对旁观者和延迟效应的发展启示。Transl Cancer Res, 3(1), 18–31.
Woolf, D. K., Williams, N. R., Bakshi, R., Madani, S. Y., Eaton, D. J., Fawcitt, S., … Keshtgar, M. (2014).乳腺癌放射治疗的生物剂量学：外照射与术中放疗的比较。SpringerPlus, 3, 329.
9。生活质量与美容效果

Coombs, N. J., Coombs, J. M., Vaidya, U. J., Singer, J., Bulsara, M., Tobias, J. S., … Vaidya, J. S. (2016).乳腺癌靶向术中放疗的环境和社会效益：从英国TARGIT-A试验中心和提供TARGIT IORT数据的两家英国NHS医院。BMJ Open, 6(5).

Corica, T., Joseph, D., Saunders, C., Bulsara, M., Nowak, A. K. (2014).早期乳腺癌术中放疗：医护人员选择方便还是风险？Radiation Oncology, 9(1), 1–9.

Corica, T., Nowak, A. K., Saunders, C. M., Bulsara, M., Taylor, M., Vaidya, J. S., … Joseph, D. J. (2016).早期乳腺癌术中放疗后的美容和乳腺相关的生活质量结果：TARGIT-A试验字研究。International Journal of Radiation Oncology*Biology*Physics, 96(1), 55–64.

Cardoso, M. J., Cardoso, J. S., Oliveira, H. P., Gouveia, P. (2016).乳腺癌保守治疗。美容效果– BCCT.core – 对乳腺癌保守治疗的美学效果客观评价软件：叙事评论。Computer Methods and Programs in Biomedicine, 126, 154–159.

Cracco, S., Semprini, G., Cattin, F., Gregoraci, G., Zeppieri, M., Isola, M., … Parodi, P. C. (2015).肿瘤乳腺手术后术中放疗对美容效果和并发症的影响。The Breast Journal, 21(3), 285–290

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013).乳腺癌靶向放疗后美容效果的客观评价：随机对照试验结果。Breast Cancer Research and Treatment, 140(3), 519–525.

Massa, M., Meszaros, P., Baldelli, I., Bisso, N., Franchelli, S. (2015).整型和保乳手术的审美评价：比较分析。Plast Reconstr Surg Glob Open, 3(3), e339.

Ng, J., Dai, T. (2016).放射治疗和异位效应：一个概念的时代到来。Annals of Translational Medicine, 4(6), 118–118.

Soror, T., Kovács, G., Kovács, Á., Seibold, N., Melchert, C., Baumann, K., … Stojanovic-Rundic, S. (2016).报告基于非标准化照片的乳房乳腺保守治疗之后的新目标方法：目标乳房大小。Brachytherapy, [Epub ahead of print].

Welzel, G., Hofmann, F., Blank, E., Kraus-Tiefenbacher, U., Hermann, B., Sütterlin, M., Wenz, F. (2010).使用低剂量的X射线进行乳腺癌保乳手术和术中放疗后的健康相关生活质量。Annals of Surgical Oncology, 17(S3), 359–367.

Yu, T., Eom, K. Y., Jang, N. Y., Kim, K. S., Koo, T. R., Kwon, J., … Kim, I. A. (2016).使用BCCT.core进行乳腺癌保乳治疗美容效果的客观测量。Cancer Research and Treatment, 48(2), 491–498.
10。IORT概览

Biggs, D. S., Thomson, E. S. (1996).手术放射治疗微型X线设备的辐射特性。The British Journal of Radiology, 69(822), 544–7.

Calvo, F. A. (2017).术中照射：精准医学促进癌症控制。Radiation Oncology, 12(1), 36.

Calvo, F. A., Sole, C. V, González, M. E., Tangco, E. D., López-Tarjuelo, J., Koubychine, I., … Ferrer, C. (2013).术中放疗的研究机会：未来十年2013 - 2023。Clinical and Translational Oncology, 15(9), 683–690.

Coles, C. E., Yarnold, J. R. (2016).加速部分乳腺照射：新标准？The Lancet, 387(10015), 201–202.

Debenham, B. J., Hu, K. S., Harrison, L. B. (2013).术中放疗的现状与展望。The Lancet Oncology, 14(11), e457–e464.

Eaton, D. J. (2015).电子近距离放射治疗——现状及未来发展方向。The British Journal of Radiology, 88(1049), 20150002.

Holmes, D. R. (2015).术中放疗治疗早期乳腺癌：已经成熟。The Breast Journal, 21(2), 181–184.

Mooney, H. (2014).NICE走在乳腺癌光子放射治疗前面。BMJ, 349(jul28 6), g4863–g4863.

Kalakota, K., Small, W. (2014).术中放疗技术与乳腺癌的选择。Expert Review of Medical Devices, 11(3), 265–73.

Paolo, V., De Lorenzi Francesca, Pietro, L., Mario, R., Umberto, V. (2016).在有植入体的妇女中乳腺癌肿瘤和手术治疗的当前趋势：发病率，诊断和治疗。Aesthetic Plastic Surgery, 40(2), 256–265.

Thariat, J., Hannoun-Levi, J.-M., Sun Myint, A., Vuong, T., Gérard, J.-P. (2012).放射治疗的过去、现在和未来。Nature Reviews Clinical Oncology, 10(1), 52–60.

Tobias, J. S., Vaidya, J. S., Keshtgar, M., D’Souza, D. P., Baum, M. (2004).早期乳腺癌放疗剂量降低：适形术中放疗的概念。The British Journal of Radiology, 77(916), 279–84.
11。临床应用指南

AGO.(2014)。原发性和转移性乳腺癌的诊断和治疗指南(版本.1).

Aetna.(2015)。Intraoperative Radiation Therapy (IORT).

DEGRO.(n.d.)。Leitlinie zur Weiterbildung zum Facharzt für Strahlentherapie.

Gnant, M., Harbeck, N., Thomssen, C. (2011).St. Gallen 2011:共识讨论综述。Breast Care, 6(2), 136–141.

Goldhirsch, A., Wood, W. C., Coates, A. S., Gelber, R. D., Thürlimann, B., Senn, H. J. (2011).亚型治疗乳腺癌多样性的策略：早期乳腺癌治疗方面的2011圣加仑国际专家共识亮点。Annals of Oncology, 22(8), 1736–1747.

NCCN.(2015)。NCCN Clinical Practice Guidelines in Oncology - Breast Cancer.

NCCN.(2016)。NCCN Clinical Practice Guidelines in Oncology - Colon Cancer.

NCCN.(2016)。NCCN Clinical Practice Guidelines in Oncology - Rectal Cancer.

Polgár, C., Limbergen, E. Van, Pötter, R., Kovács, G., Polo, A., Lyczek, J., … Strnad, V. (2010).保乳手术后加速部分乳腺照射(APBI)患者选择：集团Européen de Curiethérapie推荐——欧洲社会放射治疗及肿瘤(GEC-ESTRO) 乳腺癌工作组。Radiotherapy and Oncology, 94(3), 264–273.

Sedlmayer, F., Sautter-Bihl, M. L., Budach, W., Dunst, J., Fastner, G., Feyer, P., … Sauer, R. (2013).DEGRO实用指南：乳腺癌I期放射治疗：浸润性乳腺癌保乳治疗后的放射治疗。Strahlentherapie Und Onkologie, 189(10), 825–833.

Smith, B. D., Arthur, D. W., Buchholz, T. A., Haffty, B. G., Hahn, C. A., Hardenbergh, P. H., … Harris, J. R. (2009).美国放射肿瘤学会加速部分乳腺照射共识声明 (ASTRO)。International Journal of Radiation Oncology*Biology*Physics, 74(4), 987-1001.
12。临床试验

Institut du Cancer de Montpellier - Val d'Aurelle.术中放疗(IORT)和局部复发乳腺癌后的二次乳腺癌保乳术的可行性临床试验。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02386371.

Liao Ning.保留乳头乳房切除术后有乳腺导管原位癌的妇女的术中放疗。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02389686.

Liao Ning.治疗乳腺导管原位癌妇女的保乳术后的术中放疗。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02389673.

Loyola University.术中放疗联合椎体后凸成形术治疗脊柱转移瘤。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02480036.

Loyola University.低剂量术中辐射对可切除胰腺癌患者的一期研究。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年7月14日引用]。NLM 标识符:NCT02599662

Universitätsmedizin Mannheim.术中放疗新诊断的多形性胶质母细胞瘤的多中心III期随机临床试验 (INTRAGO II)。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02685605.

Universitätsmedizin Mannheim.INTRAGO-胶质母细胞瘤术中放疗 - I/II期研究。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02104882.

Universitätsmedizin Mannheim.椎体后凸成形术和椎体成形术(Kypho-IORT)与椎体转移瘤治疗EBRT 期间的术中放疗—— 一项随机前瞻性III期研究 ——。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年7月14日引用]。NLM 标识符:NCT02773966.

Universitätsmedizin Mannheim.患小乳腺癌的患者中进行的术中放疗(IORT) 的TARGIT-C(固结) 前瞻性IV期研究。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02290782.

Universitätsmedizin Mannheim.术中靶向放疗与INTRABEAM-系统作为乳腺癌患者的高级推量—— 德国的质量控制注册表 (TARGIT BQR)。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT01440010.

University College, London.一项国际随机对照试验，比较有局部复发高风险的妇女乳腺癌切除术后，靶向术中放疗推量与常规外照射放疗推量。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT01792726.

University of California, San Francisco.美国术中靶向放疗 (TARGIT-US)IV期注册试验：乳腺癌保乳术后靶向放射治疗的注册表试验。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT01570998.

University of Dundee.采用光子放射治疗系统(PRS)进行术中放疗 (IORT)治疗直肠癌：I期临床试验。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT00910494.
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蔡司术中放疗案例

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¹ Cognetta, A. B., Howard, B. M., Heaton, H. P., Stoddard, E. R., Hong, H. G., & Green, W. H. (2012). Superficial x-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients. Journal of the American Academy of Dermatology, 67(6), 1235–41.
² Tward, J.D., Anker, C, J,. Gaffney, D.K., Bowen, G. . (2012). Radiation Therapy and Skin Cancer. Modern Practices in Radiation Therapy, 207–246
³ Chan, S., Dhadda, A.S. (2007) Swindell, R., Single fraction radiotherapy for small superficial carcinoma of the skin. Clin Oncol (R Coll Radiol), 19(4), 256-9.