脊柱-IORT

治疗

对于许多在其病程中发生脊柱转移瘤的癌症患者来说，最近的一项随机试验证实经皮骨水泥强化是一项有价值的治疗选择。¹ 骨水泥强化期间通过蔡司INTRABEAM^® 进行术中放疗，可以灭活转移瘤，同时稳定脊椎，这一治疗可以迅速减轻患者痛苦。

该方法的初次临床试验经验已经取得了非常可喜的结果，术中风险预测与骨水泥强化相似，与传统的单次放疗相比，减少了治疗时间及住院时间，为患者提供了更多便利。^2,3

治疗步骤

第 1步 定位肿瘤。

第2步 使用X射线引导，产生一微创的接入点。

第3步 放置施用器。

第4步 准确进行骨转移照射 (<5 min) 。

第5a步 通过椎体成形术或其他稳定脊椎...

第5b步 ... 球囊椎体后凸成形术。

文献

文献一览

1。脑瘤

Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., … Eljamel, S. (2007).术中放疗服务的实施与体会。Clinical Oncology, 19(3), S8–S9.

Brehmer, S., Guthier, C. V, Clausen, S., Schneider, F., Schulte, D. M., Benker, M., … Giordano, F. A. (2016).结合立体定向活检和步进源组织间照射晚期多形性胶质母细胞瘤。Journal of Neurosurgical Sciences.

Cosgrove, G. R., Hochberg, F. H., Zervas, N. T., Pardo, F. S., Valenzuela, R. F., & Chapman, P. (1997).使用微型放射外科设备的脑肿瘤的间质照射：初步经验。Neurosurgery, 40(3), 518-23–5.

Dinsmore, M., Yanch, J. C., Sliski, A. P., & Harte, K. J. (1994).用于间质放射治疗的新型X射线发生器。Transact.Amer.Nuclear Soc., 70, 24–25.

Eljamel, M. S., Liaguart, I., Perry, J., Mowle, D., Ballantyne, E., Ackland, C., & Munro, A. (2008).Intraoperative radiotherapy using mobile miniture X-ray source in malignant brain tumors.

Giordano, F. A., Brehmer, S., Abo-Madyan, Y., Welzel, G., Sperk, E., Keller, A., … Wenz, F. (2014).INTRAGO：胶质母细胞瘤的术中放疗 —— I / II期剂量递增研究。BMC Cancer, 14(1), 992.

Giordano, F. A., Brehmer, S., Muerle, B., Welzel, G., Sperk, E., Schneider, F., … Wenz, F. (2016).初诊胶质母细胞瘤(INTRAGO)术中放射治疗(IORT)1/2期试验的初步结果。International Journal of Radiation Oncology, Biology, Physics, 96(2S), E67–E68.

Giordano, F. A., Wenz, F., & Petrecca, K. (2016).胶质母细胞瘤术中放疗的原理。Journal of Neurosurgical Sciences, 60(3), 350–6.

Gzell, C., Back, M., Wheeler, H., Bailey, D., & Foote, M. (2016).胶质母细胞瘤的放射治疗：过去、现在与未来。Clinical Oncology.

Han, X., Fu, B., Wu, M., Zhang, H., Li, D., Zhang, J., … Sun, S. (2014).使用INTRABEAM进行的术后原发性脑肿瘤的术中放疗：26例初步报告。Neuro-Oncology, 16.

Haneder, S., Giordano, F. A., Konstandin, S., Brehmer, S., Buesing, K. A., Schmiedek, P., … Ong, M. M. (2015).²³ 术中放疗后复发性多形性胶质母细胞瘤的Na-MRI：技术说明。Neuroradiology, 57(3), 321–326.

Kalapurakal, J. A., Goldman, S., Stellpflug, W., Curran, J., Sathiaseelan, V., Marymont, M. H., & Tomita, T. (2006).光子放射治疗系统治疗小儿复发性脑肿瘤的I期研究：第一剂量水平(10 Gy)的初步报告。International Journal of Radiation Oncology Biology Physics, 65(3), 800–808.

Kawano, H., Hirano, H., Yonezawa, H., Yunoue, S., Yatsushiro, K., Ogita, M., … Arita, K. (2015).近三年胶质母细胞瘤治疗效果的改善及影响因素。British Journal of Neurosurgery, 29(2), 206–212.

Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella-Branger, D., Cavenee, W. K., … Ellison, D. W. (2016).2016届世界卫生组织对中枢神经系统肿瘤分类的综述。Acta Neuropathologica, 131(6), 803–820.

Minafra, L., & Bravatà, V. (2014).IORT治疗的细胞和分子反应。Translational Cancer Research, 3(1), 32–47.

NCCN.(2015)。NCCN Clinical Practice Guidelines in Oncology - Central Nervous System Cancers.

Niyazi, M., Brada, M., Chalmers, A. J., Combs, S. E., Erridge, S. C., Fiorentino, A., … Belka, C. (2016).ESTRO-ACROP 方针”胶质母细胞瘤的靶区。“Radiotherapy and Oncology, 118(1), 35–42.

Seddighi, A., Akbari, M. E., Seddighi, A. S., Rakhsha, A., Vaezi, M., & Zohrevand, A. H. (2015).伊朗脑胶质瘤术中放射治疗的初步体会：三例报告及文献浏览。Iranian Journal of Cancer Prevention, 8(5).

Shcherbuk, I., Shcherbuk, Ai., Eroshenko, M., Tokarev, S., Ivanov, V., & Dovgopolaia, K. (2014).大脑大半球功能显著区转移性肿瘤的外科治疗中运动皮层映射结合术中光子治疗。Vestn Khir Im I I Grek, 173(1), 47–50.

Sologuren, I., Rodríguez-Gallego, C., & Lara, P. C. (2014).高剂量放射治疗免疫作用：电离辐射对旁观者和延迟效应的发展启示。Transl Cancer Res, 3(1), 18–31.

Takakura, K., & Kubo, O. (2000).恶性脑肿瘤的治疗。甘化学疗法。Cancer & Chemotherapy, 27 Suppl 2, 449–53.

Weil, R. J., Mavinkurve, G. G., Chao, S. T., Vogelbaum, M. a, Suh, J. H., Kolar, M., & Toms, S. a. (2015).术中放疗治疗初诊单发脑转移：初步经验和长期结果。Journal of Neurosurgery, 122(4), 825–832.

Wang, M., Maier, P., Wenz, F., Giordano, F. A., & Herskind, C. (2013).人脑胶质瘤细胞系缺乏表皮生长因子受体活化的有丝分裂信号。Journal of Neuro-Oncology, 115(3), 323–331.

Zamzuri, I., Rahman, G. I., Muzaimi, M., Jafri, a M., Nik Ruzman, N. I., Lutfi, Y. a, … Mar, W. (2012).对于高级别胶质瘤多形疗法：继术中放疗有利结果的情况报告。The Medical Journal of Malaysia, 67(1), 121–2.

2。乳腺癌

Alvarado, M. D., Mohan, A. J., Esserman, L. J., Park, C. C., Harrison, B. L., Howe, R. J., … Ozanne, E. M. (2013).早期乳腺癌术中放疗的成本-效果分析。Annals of Surgical Oncology, 20(9), 2873–80.

Alvarado, M. D., Conolly, J., Park, C., Sakata, T., Mohan, A. J., Harrison, B. L., … Ozanne, E. M. (2014).术中放疗与外照射放疗对保乳手术患者的偏好。Breast Cancer Research and Treatment, 143(1), 135–140.

Andersen, K. G., Gärtner, R., Kroman, N., Flyger, H., Kehlet, H. (2012).术中靶向放疗(TARGIT)或乳腺癌外部放疗后的持续性疼痛：随机试验。The Breast, 21(1), 46–49.

Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., … Munro, A. (2007).乳腺局部照射时极低能量X射线皮肤剂量的测量。Clinical Oncology, 19(3), S23.

Benda, R. K., Yasuda, G., Sethi, A., Gabram, S. G. A., Hinerman, R. W., & Mendenhall, N. P. (2003).乳腺推量:我们错过目标了吗？两种推量技术的剂量学比较。Cancer, 97(4), 905–909.

Corica, T., Nowak, A. K., Saunders, C. M., Bulsara, M., Taylor, M., Vaidya, J. S., … Joseph, D. J. (2016).早期乳腺癌术中放疗后的美容和乳腺相关的生活质量结果——TARGIT-A试验的子研究。International Journal of Radiation Oncology*Biology*Physics.

Darby, S. C., Ewertz, M., McGale, P., Bennet, A. M., Blom-Goldman, U., Brønnum, D., … Hall, P. (2013).女性乳腺癌放疗后缺血性心脏病的风险。New England Journal of Medicine, 368(11), 987–998

Elsberger, B., Romsauerova, A., Vinnicombe, S., Whelehan, P., Brown, D. C., Dewar, J. A., … Evans, A. (2014).术中放疗和外照射全乳腺放疗后X线表现的比较。European Journal of Surgical Oncology, 40(2), 163–167.

Esposito, E., Anninga, B., Harris, S., Capasso, I., D’Aiuto, M., Rinaldo, M., Douek, M. (2015).早期乳腺癌的术中放射治疗。British Journal of Surgery, 102(6), 599–610.

Esposito, E., Anninga, B., Honey, I., Ross, G., Rainsbury, D., Laws, S., … Douek, M. (2015).IORT准备推出了吗?Ecancermedicalscience, 9, 516.

Esserman, L. J., Alvarado, M. D., Howe, R. J., Mohan, A. J., Harrison, B., Park, C., … Ozanne, E. M. (2014).应用决策分析框架来采用临床试验结果：有关TARGIT-A IORT的数据是否准备就绪？Breast Cancer Research and Treatment, 144(2), 371–378.

Fabris, L., Berton, S., Citron, F., D’Andrea, S., Segatto, I., Nicoloso, M. S., … Belletti, B. (2016).放疗引起的miR-223通过靶向表皮生长因子通路防止乳腺癌复发。Oncogene, (November 2015), 1–13.

Grobmyer, S. R., Lightsey, J. L., Bryant, C. M., Shaw, C., Yeung, A., Bhandare, N., … Copeland, E. M. (2013).Low kilovoltage，乳腺癌的单剂量术中放射治疗：多学科乳腺癌计划的结果和影响。Journal of the American College of Surgeons, 216(4), 617–624.

Holmes, D. R., Baum, M., Joseph, D. (2007).TARGIT试验：术中靶向放射治疗与常规术后全乳放疗的保乳术后的早期浸润性乳腺癌的管理(试验更新)。American Journal of Surgery, 194(4), 507–510.

Holmes, D. R. (2014).术中放疗在保乳手术中的应用。Journal of Surgical Oncology, 110(1), 68–74.

Holmes, D. R. (2015).术中放疗治疗早期乳腺癌：已经成熟。The Breast Journal, 21(2), 181–184.

Keshtgar, M. R. S., Vaidya, J. S., Tobias, J. S., Wenz, F., Joseph, D., Stacey, C., … Baum, M. (2011).不可能外照射的乳腺癌患者的靶向术中放疗。International Journal of Radiation Oncology*Biology*Physics, 80(1), 31–38.

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013).乳腺癌靶向放疗后美容效果的客观评价：随机对照试验结果。Breast Cancer Research and Treatment, 140(3), 519–525.

Kolberg, H.-C., Loevey, G., Akpolat-Basci, L., Stephanou, M., Fasching, P. A., Untch, M., … Vaidya, J. S. (2017).新辅助化疗后乳腺癌保乳术中靶向放疗。Strahlentherapie Und Onkologie, 193(1), 62–69.

Kraus-Tiefenbacher, U., Bauer, L., Kehrer, T., Hermann, B., Melchert, F., Wenz, F. (2006).早期乳腺癌的患者中术中放疗 (IORT) 作为推量 – 急性毒性。Oncology Research and Treatment, 29(3), 77–82.

Kraus-Tiefenbacher, U., Bauer, L., Scheda, A., Fleckenstein, K., Keller, A., Herskind, C., … Wenz, F. (2006).保乳术中使用低能 X-射线的术中放疗推量的长期毒性。International Journal of Radiation Oncology*Biology*Physics, 66(2), 377–381.

Kraus-Tiefenbacher, U., Bauer, L., Scheda, A., Schoeber, C., Schaefer, J., Steil, V., Wenz, F. (2007).术中放疗 (IORT) 是在之前接受过外放射治疗后发生局部乳腺癌复发的患者的一种替代选择。BMC Cancer, 7(1), 178.

Kraus-Tiefenbacher, U., Welzel, G., Brade, J., Hermann, B., Siebenlist, K., Wasser, K. S., … Wenz, F. (2010).术中放疗使用低剂量X射线乳腺癌保乳手术期间给予术后血清肿形成。International Journal of Radiation Oncology*Biology*Physics, 77(4), 1140–1145 .

Lim, S. Z., Yong, W. S., Ho, G. H., Madhukumar, P., Wong, F. Y., Chua, E. T., … Ong, K. W. (2014).INTRABEAM术中放疗在亚洲人群中的早期经验。European Journal of Cancer, 50, S214–S215.

Malter, W., Kirn, V., Richters, L., Fridrich, C., Markiefka, B., Bongartz, R., … Kraemer, S. (2014).靶向肿瘤乳腺手术期间的术中推量放疗：概述和单中心经验。International Journal of Breast Cancer, 1–6.

Massa, M., Franchelli, S., Panizza, R., Massa, T. (2016).目前的临床实践是否就术中乳房照射进行了改良？Chinese Journal of Cancer Research, 28(2), 146–149.

Merdad, A. A., Bahadur, Y. A., Fawzy, E. E., Hassouna, A. H., Eltaher, M. M., Alghaithy, Z. K., … Constantinescu, C. T. (2013).早期乳腺癌术中放疗的II期研究。Saudi Medical Journal, 34(11), 1133–8.

Mooney, H. (2014).NICE走在乳腺癌光子放射治疗前面。BMJ, 349(jul28 6), g4863–g4863.

Pan, L., Zheng, W., Ye, X., Chen, L., Ke, Y., Wan, M., … Zhang, X. (2014).保留乳头乳房切除术和乳房重建的INTRABEAM术中放疗方法。Clinical Breast Cancer, 14(6), 435–441.

Picot, J., Copley, V., Colquitt, J. L., Kalita, N., Hartwell, D., Bryant, J. (2015).用于早期乳腺癌辅助治疗的INTRABEAM®光子放射治疗系统 :系统评价与经济评价。Health Technology Assessment, 19(69), 1–190.

Preuss, J., Lester, L., Saunders, C. (2012).BCCT.core – 计算机程序可以用于乳房重建手术后的审美结果的评估吗？The Breast, 21(4), 597–600.

Rivera, R., Banks, A., Casillas-Lopez, A., Rashtian, A., Lewinsky, B., Sheth, P., … Holmes, D. R. (2016).靶向术中放疗治疗乳腺导管内癌。The Breast Journal, 22(1), 63–74.

Ruano-Ravina, A., Cantero-Muñoz, P., Eraso Urién, A. (2011).乳腺癌术中放疗的疗效与安全性：系统回顾。Cancer Letters, 313(1), 15–25.

Sedlmayer, F., Reitsamer, R., Wenz, F., Sperk, E., Fussl, C., Kaiser, J., … Fastner, G. (2017).术中放疗(IORT)作为乳腺癌中的推量。Radiation Oncology, 12(1), 23.

Sedlmayer, F., Zehentmayr, F., Fastner, G. (2013).局部乳腺再次照射治疗乳腺癌局部复发：获益与长期副作用。The Breast, 22, S141–S146.

Sperk, E., Welzel, G., Keller, A., Kraus-Tiefenbacher, U., Gerhardt, A., Sütterlin, M., Wenz, F. (2012).Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomised phase III trial TARGIT A. Breast Cancer Research and Treatment, 135(1), 253–260.

Sperk, E., Astor, D., Keller, A., Welzel, G., Gerhardt, A., Tuschy, B., … Wenz, F. (2014).队列分析确定早期乳腺癌术中放射治疗(IORT)的患者。Radiation Oncology, 9(1), 154.

Vaidya, J. S., Baum, M., Tobias, J. S., Massarut, S., Wenz, F., Murphy, O., … Joseph, D. (2006).给送推量时，术中靶向放疗(TARGIT)产生极低的复发率。International Journal of Radiation Oncology*Biology*Physics, 66(5), 1335–1338.

Vaidya, J. S., Joseph, D. J., Tobias, J. S., Bulsara, M., Wenz, F., Saunders, C., … Baum, M. (2010).靶向术中放疗与全乳放疗治疗乳腺癌的比较(TARGIT-A试验)：一项国际前瞻性随机非劣效性3期试验。The Lancet, 376(9735), 91–102.

Vaidya, J. S., Baum, M., Tobias, J. S., Wenz, F., Massarut, S., Keshtgar, M., … Joseph, D. (2011).保乳手术中靶向术中放疗 (Targit)推量的长期结果。International Journal of Radiation Oncology*Biology*Physics, 81(4), 1091-1097.

Vaidya, J. (2013).“1-stop” radiotherapy could offer an alternative to lengthy and inconvenient post-surgery procedures for breast cancer

Vaidya, J. S., Wenz, F., Bulsara, M., Tobias, J. S., Joseph, D. J., Keshtgar, M., … Baum, M. (2014).风险适应的乳腺癌靶向术中放疗vs全乳腺放疗：TARGIT-A随机试验中局部控制及总生存率的5年结果。The Lancet, 383(9917), 603–613.

Vaidya, J. S., Bulsara, M., Wenz, F., Joseph, D., Saunders, C., Massarut, S., … Baum, M. (2015).傲慢、偏见或科学：对乳腺癌靶向术中放疗的TARGIT-A试验结果的态度。International Journal of Radiation Oncology Biology Physics, 92(3), 491–497.

Vaidya, J. S., Bulsara, M., Wenz, F., Coombs, N., Singer, J., Ebbs, S., … Baum, M. (2016).早期乳腺癌部分乳腺照射降低死亡率--随机试验meta分析。International Journal of Radiation Oncology*Biology*Physics, 1–7.

Valente, S. A., Tendulkar, R. D., Cherian, S., O’Rourke, C., Greif, J. M., Bailey, L., … Grobmyer, S. R. (2016).TARGIT-R (回顾性):使用低剂量X射线行乳腺癌术中辐射的北美经验。Annals of Surgical Oncology.

Wasser, K., Schoeber, C., Kraus-Tiefenbacher, U., Bauer, L., Brade, J., Teubner, J., … Neff, W. (2007).术中放疗(IORT)作为乳腺癌患者推量后的早期X线和超声检查。European Radiology, 17(7), 1865–74.

Welzel, G., Blank, E., Kraus-Tiefenbacher, U., Keller, A., Vorodi, F., Herskind, C., … Wenz, F. K. (2008).乳腺癌保乳手术和外放疗(EBRT)期间IORT之间的间隔对晚期毒性的影响。Journal of Clinical Oncology, 26, 630.

Welzel, G., Boch, A., Sperk, E., Hofmann, F., Kraus-Tiefenbacher, U., Gerhardt, A., … Wenz, F. (2013).Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomised phase III trial TARGIT-A. Radiation Oncology, 8(1), 9.

Wenz, F., Welzel, G., Keller, A., Blank, E., Vorodi, F., Herskind, C., … Kraus-Tiefenbacher, U. (2008).外照射放疗(EBRT)早期可能增加进行术中放疗(IORT)作为乳腺癌推量的患者的长期毒性的风险。Breast, 17(6), 617–622.

Wenz, F., Welzel, G., Blank, E., Hermann, B., Steil, V., Sütterlin, M., Kraus-Tiefenbacher, U. (2010).使用低剂量X射线乳腺癌保乳手术期间术中放疗作为推量：使用创新方法的首五年经验。International Journal of Radiation Oncology*Biology*Physics, 77(5), 1309–1314.

Wenz, F., Blank, E., Welzel, G., Hofmann, F., Astor, D., Neumaier, C., … Kraus-Tiefenbacher, U. (2012).使用微型X射线发生器(intrabeam®)行乳腺癌保乳手术的术中放疗：理论和实验背景和临床经验。Women’s Health, 8(1), 39–47.

Wenz, F., Sedlmayer, F., Herskind, C., Welzel, G., Sperk, E., Neumaier, C., … Sütterlin, M. (2015).临床实践中的加速乳腺部分照射。Breast Care, 10(4), 247–252.

Williams, N. R., Pigott, K. H., Brew-Graves, C., Keshtgar, M. R. S. (2014).乳腺癌术中放疗。Gland Surgery, 3(2), 109–119.

3。胃肠道肿瘤

Algur, E., Mahadevan, A., Deibel, C. (2005).间质光子放射治疗系统治疗复发和局部晚期直肠癌：24例回顾性分析。ASCO Gastrointestinal Cancers Symposium, Jan 27–29, Hollywood, Florida, USA, Abstract No 208.

Brady, J. T., Crawshaw, B. P., Murrell, B., Dosokey, E. M. G., Jabir, M. A., Steele, S. R., … Reynolds, H. L. (2017).术中放疗对局部晚期复发性结直肠肿瘤的影响：16-年经验。The American Journal of Surgery.

Guo, S., Reddy, C. A., Kolar, M., Woody, N., Mahadevan, A., Deibel, F., … Suh, J. H. (2012).光子放射治疗系统在局部晚期和复发直肠癌中的放射治疗：克利夫兰临床经验回顾。Radiation Oncology, 7(1), 110.

Haddock, M. G. (2016).局部晚期和复发性直肠癌的照射。Seminars in Radiation Oncology, 26(3), 226–235.

Haddock, M. G. (2017).术中放疗治疗结直肠癌的临床观察。Radiation Oncology, 12(1), 11.

Lyadov, K., Krymskiy, V., Markin, A., Krymskiy, A. (2008).胃癌的综合治疗中使用intra beam系统的术中辐射安全性评价。Poster Abstract Presented at the ISIORT Meeting.

Lyadov, K., Yu, S., Krymskiy, V., Krymskiy, A. (2008).由于使用INTRA BEAM系统进行术中接触放射治疗导致的结直肠癌视频辅助手术的治疗改进。ISIORT.

National Comprehensive Cancer Network® - Guidelines for Colon & Rectal Cancer, 2016

Polkowski, W. P., Skórzewska, M. (2014).低能量光子术中放疗在直肠癌复发中的应用。(M. Keshtgar, K. Pigott, & F. Wenz, Eds.), Targeted Intraoperative Radiotherapy in Oncology.柏林, 海德堡:Springer Berlin Heidelberg.

Potemin, S., Uvarov, I., Vasilenko, I. (2015).局部晚期复发直肠癌术中放疗68例回顾性分析。Transl Cancer Res, 4(2), 189–195.

Skórzewska, M., Mielko, J., Kurylcio, A., Romanek, J., Polkowski, W. P. (2016).低能量光子术中放疗治疗复发性结直肠癌：单中心回顾性研究。Współczesna Onkologia, 20(1), 52–57.

Susko, M., Lee, J., Salama, J., Thomas, S., Uronis, H., Hsu, D., … Palta, M. (2016).再照射在局部复发、非转移性直肠癌中的应用。外科肿瘤学纪事。

4。头 & 颈部肿瘤

Abo-Madyan, Y., Gößler, U., Vent, J., Nwankwo, C., Schneider, F., Hörmann, K., Wenz, F. (2013).使用移动50kV微型加速器术中放疗复发性头 & 颈部鳞状细胞癌。DEGRO 2013, Poster.

Chen, A. M., Bucci, M. K., Singer, M. I., Garcia, J., Kaplan, M. J., Chan, A. S., Phillips, T. L. (2007).术中放疗治疗复发性头颈部肿瘤：UCSF的经验。International Journal of Radiation Oncology*Biology*Physics, 67(1), 122–129.

De Felice, F., Musio, D., Tombolini, V. (2016).复发性头颈癌的术中放疗(IORT)。Oral Oncology, 55(March), e1.

Kyrgias, G., Hajiioannou, J., Tolia, M., Kouloulias, V., Lachanas, V., Skoulakis, C., … Bizakis, I. (2016).头颈癌的术中放疗(IORT)：系统回顾。Medicine, 95(50), e5035.

Münter, M. W., Köppen, U., Ramuscak, A., Sittel, C., Wegner, N. (2015).术中放疗(IORT)在头部和颈部癌症方面的治疗。Transl Cancer Res, 4(2), 178–181.

Roopashri, G., Baig, M. (2013).头颈部恶性肿瘤放射治疗的研究进展。Journal of International Oral Health, 5(6), 119–23.

Rutkowski, T., Wygoda, A., Hutnik, M., Składowski, K., Wydmański, J., Maciejewski, A., … Maciejewski, B. (2010).使用低能量光子进行术中放疗(IORT)作为有术后放疗适应症的早期口腔癌患者的推量治疗：治疗便利性和初步结果。Strahlentherapie Und Onkologie, 186(9), 496–501.

5。非-黑色素瘤皮肤癌

Amini, S., Viera, M. H., Valins, W., Berman, B. (2010).非黑素瘤皮肤癌治疗的非手术治疗的创新。The Journal of Clinical and Aesthetic Dermatology, 3(6), 20–34.

Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., … Munro, A. (2007).乳腺局部照射时极低能量X射线皮肤剂量的测量。Clinical Oncology, 19(3), S23.

Bhatnagar, A., Loper, A. (2010).电子近距离放射治疗非黑色素瘤皮肤癌的初步经验。Radiation Oncology (London, England), 5, 87.

Chan, S., Dhadda, A.S.(2007) Swindell, R., Single fraction radiotherapy for small superficial carcinoma of the skin.Clin Oncol (R Coll Radiol), 19(4), 256-9.

Cognetta, A. B., Howard, B. M., Heaton, H. P., Stoddard, E. R., Hong, H. G., Green, W. H. (2012).浅表X线在基底细胞癌和鳞状细胞癌治疗中的应用：选择患者中可行的选择。Journal of the American Academy of Dermatology, 67(6), 1235–41.

Bodner, W. R., Hilaris, B. S., Alagheband, M., Safai, B., Mastoras, C. A., Saraf, S. (2003).浅表非黑色素瘤皮肤癌治疗中的的低能量X -射线的使用。Cancer Investigation, 21(3), 355–362.

Ducassou, A. (2015).INTRABEAM在 IUCT Oncopole Toulouse的皮肤治疗初体验。In ESTRO proceeding.

Ermertcan, A. T., Hellings, P. W., Cingi, C. (2012).头部和颈部的非黑素瘤皮肤癌的非手术治疗。Facial Plastic Surgery Clinics of North America, 20(4), 445–54.

Goubert, M., Parent, L. (2015).INTRABEAM®小型加速器平板和表面施用器关于皮肤病学的剂量学特性。Physica Medica, 31(3), 224–232.

Jankarashvili, N., Topeshashvili, M. (2015).用 intrabeam治疗皮肤癌。9th ZEISS INTRABEAM User Meeting.

Levell, N. J., Igali, L., Wright, K. A., Greenberg, D. C. (2013).英国基底细胞癌流行病学：室内象。Clinical and Experimental Dermatology, 38(4), 367–9.

Nguyen, T. H., Ho, D. Q.-D. (2002).非黑色素瘤皮肤癌。Current Treatment Options in Oncology, 3(3), 193–203.

Perkins, J. L., Liu, Y., Mitby, P. A., Neglia, J. P., Hammond, S., Stovall, M., … Mertens, A. C. (2005).儿童和青少年癌症幸存者的非黑素瘤皮肤癌：一项儿童癌症幸存者的研究报告。Journal of Clinical Oncology, 23(16), 3733–41.

Tward, J.D., Anker, C, J,.Gaffney, D.K., Bowen, G. .(2012)。放射治疗与皮肤癌。Modern Practices in Radiation Therapy, 207–246.

6。脊柱转移瘤

Berenson, J., Pflugmacher, R., ..., Jarzem, P. (2011) Cancer Patient Fracture Evaluation (CAFE) lnvestigators.球囊扩张椎体后凸成形术与非手术骨折治疗癌症患者疼痛性椎体压缩骨折的多中心、随机对照试验。Lancet Oncology, 12(3), 225-35.

Bludau, F., Obertacke, U., Schmidt, R. (2012).Kypho IORT后的首次中期结果。European Spine Journal, 21(11), 2332.

Bludau, F. (2014).脊柱-IORT：脊柱转移瘤术中放疗：九个月临床结果。The Spine Journal, 14(11), S163

Bludau, F., Reis, T., Schneider, F., Clausen, S., Wenz, F., Obertacke, U. (2015).椎体后凸成形术结合术中放疗 (Kypho-IORT)。Der Radiologe, 55(10), 859–867.

Kayser, R., Ender, S. A., Asse, E., Wilhelm, E., Adler, F., Schmidt, R., … Bludau, F. (2013).椎体后凸成形术结合术中放疗。Der Orthopäde, 42(9), 765–771.

Miglierini, P., Dam-Hieu, P., Key, S. (2014).Kypho-IORT:首个法国治疗。Translational Cancer Research, 3(1).

Reis, T., Schneider, F., Hermann, B., Bohrer, M., Schmitt, R., Obertacke, U., Wenz, F. (2010).脊柱-IORT：椎体后凸成形术中放疗治疗脊柱转移瘤。International Journal of Radiation Oncology Biology Physics, 78(3), S581–S582.

Reis, T., Schneider, F., Welzel, G., Schmidt, R., Bludau, F., Obertacke, U., Wenz, F. (2012).椎体转移瘤椎体后凸成形术(Kypho IORT)期间的术中放疗：首批临床结果。Tumori, 98(4), 434–40.

Reis, T., Sperk, E., Schneider, F., Schmidt, R., Obertacke, U., Wenz, F. (2012).脊柱转移瘤的Kypho-IORT: 病例研究。Hospital Oncology & Haematology Europe, Campden Publishing Ltd, Apr, 21-24.

Schmidt, R., Obertacke, U., Wenz, F., Reis, T., Schneider, F. (2010).一项新的关于脊柱转移瘤微创术中放疗结合球囊扩张椎体后凸成形术(Kypho IORT)的临床可行性。European Spine Journal, 19(11), 2049.

Schmidt, R., Wenz, F., Reis, T., Janik, K., Bludau, F., Obertacke, U. (2012).椎体后凸成形术和术中放疗，脊柱转移瘤椎体后凸成形术和术中辐射相组合：一种新方法的技术可行性。International Orthopaedics, 36(6), 1255–1260.

Schneider, F., Greineck, F., Clausen, S., Mai, S., Obertacke, U., Reis, T., Wenz, F. (2011).脊柱转移瘤椎体后凸成形术 (Kypho-IORT)期间术中放疗新方法的建立。International Journal of Radiation Oncology*Biology*Physics, 81(4), 1114–1119.

Wenz, F., Schneider, F., Neumaier, C., Kraus-Tiefenbacher, U., Reis, T., Schmidt, R., Obertacke, U. (2010).Kypho-IORT – 脊柱转移瘤椎体后凸成形术的术中放疗的新方法。Radiation Oncology, 5(1), 11.

7。医学物理学

Armoogum, K. S., Parry, J. M., Souliman, S. K., Sutton, D. G., Mackay, C. D. (2007).术中放疗设备功能比对——光子放射治疗系统。Radiation Oncology, 2(1), 11.

Eaton, D. J., Duck, S. (2010).术中X射线装置的剂量测量。Physics in Medicine and Biology, 55(12), N359–N369.

Eaton, D. J., Gonzalez, R., Duck, S., Keshtgar, M. (2011).术中X射线装置的辐射保护。The British Journal of Radiology, 84(1007), 1034–1039.

Eaton, D. J., Best, B., Brew-Graves, C., Duck, S., Ghaus, T., Gonzalez, R., … Keshtgar, M. R. S. (2012).乳腺癌的单组术中靶向放疗(TARGIT)的体内剂量。International Journal of Radiation Oncology*Biology*Physics, 82(5), e819–e824.

Eaton, D. J. (2012).术中X射线装置的质量保证和独立剂量测定。Medical Physics, 39(11), 6908.

Ebert, M. A., Asad, A. H., Siddiqui, S. A. (2009).对于非常低能量X射线剂量的辐射变色薄膜的适宜性。Journal of Applied Clinical Medical Physics / American College of Medical Physics, 10(4), 2957.

Cardoso, M. J., Cardoso, J. S., Oliveira, H. P., Gouveia, P. (2016).乳腺癌保守治疗。美容效果– BCCT.core – 对乳腺癌保守治疗的美学效果客观评价软件：叙事评论。Computer Methods and Programs in Biomedicine, 126, 154–159.

Chiavassa, S., Buge, F., Hervé, C., Delpon, G., Rigaud, J., Lisbona, A., Supiot, S. (2015).盆腔中低能量光子术中放疗剂量计算的不均匀性影响的蒙特卡洛评估。Physica Medica, 31(8), 956–962.

Darby, S. C., Ewertz, M., McGale, P., Bennet, A. M., Blom-Goldman, U., Brønnum, D., … Hall, P. (2013).女性乳腺癌放疗后缺血性心脏病的风险。New England Journal of Medicine, 368(11), 987–998.

Eaton, D. J., Earner, B., Faulkner, P., Dancer, N. (2013).术中放疗的国家剂量学审核。The British Journal of Radiology, 86(1032), 20130447.

Emami, B., Woloschak, G., Small Jr, W. (2015).超越线性二次模型 ：术中放疗和正常组织耐受性。Transl Cancer Res, 4(2), 140–147.

Goubert, M., Parent, L. (2015).INTRABEAM^®小型加速器平板和表面施用器关于皮肤病学的剂量学特性。Physica Medica, 31(3), 224–232.

Härtl, P. M., Dobler, B., Kölbl, O., Treutwein, M. (2009).Intrabeam^®(蔡司)放射进行术中治疗的实用剂量测定和密度。Zeitschrift Für Medizinische Physik, 19(4), 288–293.

Hill, R., Healy, B., Holloway, L., Kuncic, Z., Thwaites, D., Baldock, C. (2014).千伏X射线束剂量学研究进展。Physics in Medicine and Biology, 59(6), R183–R231.

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013).乳腺癌靶向放疗后美容效果的客观评价：随机对照试验结果。Breast Cancer Research and Treatment, 140(3), 519–525.

Xu, Y., & Lam, S. (2013).蔡司IntraBeam平板和表面施用器的剂量学特点。Medical Physics, 40(6), 284–284.

Lam, S. C. P., Xu, Y., West, M. (2016).低-KVIORT向前突出施用器的屏蔽效果。EC Cancer, 2(1), 64–75.

Muralidhar, K. R., Rout, B., Mallikarjuna, A., Poornima, A., Murthy, P. N. (2014).Intrabeam术中放疗设备的试行和质量保证。International Journal of Cancer Therapy and Oncology, 2(4), 20415.

Nwankwo, O., Clausen, S., Schneider, F., Wenz, F. (2013).一种高压放射治疗设备的虚拟源模型。Physics in Medicine and Biology, 58(7), 2363–2375.

Preuss, J., Lester, L., Saunders, C. (2012).BCCT.core – 计算机程序可以用于乳房重建手术后的审美结果的评估吗？The Breast, 21(4), 597–600.

Price, C., Pederson, A., Frazier, C., Duttenhaver, J. (2013).乳腺癌术中放疗的光刺激剂量计的体内剂量和RTQA2辐射变色薄膜。Medical Physics, 40(9), 91716.

Schneider, F., Clausen, S., Jahnke, A., Steil, V., Bludau, F., Sütterlin, M., … Wenz, F. (2014).相比于C型臂透视技术的术中X-射线源的辐射防护。Zeitschrift Fur Medizinische Physik, 24(3), 243–251.

Schneider, F., Clausen, S., Thölking, J., Wenz, F., Abo-Madyan, Y. (2014).使用50kV X射线源的浅表性术中放疗的新方法(IORT)：技术和病例报告。Journal of Applied Clinical Medical Physics / American College of Medical Physics, 15(1), 4502.

Sethi, A., Chinsky, B., Gros, S., Diak, A. (2015).低kV术中放疗 (IORT)的组织不均匀性校正。Translational Cancer Research, 4(2), 182–188.

Steenbeke, F., Gevaert, T., Tournel, K., Engels, B., Verellen, D., Storme, G., Ridder, M. D. (2015).使用EBT3 GafChromic膜的50-kV放疗单位的质量保证：可行性研究。Technology in Cancer Research & Treatment, 15(1), 163–70.

Watson, P. G. F., Seuntjens, J. (2016).技术说明:显M和N-壳原子跃迁对低能X射线源的影响。Medical Physics, 43(4), 1760–1763.

Wuu, C.-S., Sheu, R.-D., Chen, J. (2015).在不同深度乳腺癌术中放疗的50 kV X射线的微剂量学特性。Radiation Protection Dosimetry, 166(1–4), 343–6.

8。放射生物学

Belletti, B., Vaidya, J. S., D’Andrea, S., Entschladen, F., Roncadin, M., Lovat, F., … Massarut, S. (2008).靶向术中放疗削弱了乳腺癌细胞增殖刺激和手术创伤造成的侵袭。Clinical Cancer Research, 14(5), 1325–1332.

Fabris, L., Berton, S., Citron, F., D’Andrea, S., Segatto, I., Nicoloso, M. S., … Belletti, B. (2016).放疗引起的miR-223通过靶向表皮生长因子通路防止乳腺癌复发。Oncogene, (February 2016), 1–13.

Herskind, C., Griebel, J., Kraus-Tiefenbacher, U., Wenz, F. (2008).使用低能量X射线术中放疗的新靶体积概念——等价球体。International Journal of Radiation Oncology*Biology*Physics, 72(5), 1575–1581.

Herskind, C., Ma, L., Liu, Q., Zhang, B., Schneider, F., Veldwijk, M. R., & Wenz, F. (2017).高剂量的IORT生物学：RBE, 5 R, 和其他生物方面。Radiation Oncology (London, England), 12(1), 24.

Herskind, C., Schalla, S., Hahn, E. W., Höver, K.-H., ..., Wenz, F. (2006)."旷日持久的适形放疗中，不同空间位置细胞恢复和RBE的不同剂量率的影响。"Radiation protection dosimetry, 122 (1-4), 498-505.

Herskind, C., Wenz, F. (2010).大分割加速部分乳腺照射(APBI)和50 kV X射线的单剂量术中放疗(IORT)的放射生物学的比较。Strahlentherapie Und Onkologie, 186(8), 444–451.

Herskind, C., Wenz, F. (2014).低能量X射线术中瘤床照射( LEX-IORT )的放射生物学方面。Transl Cancer Res, 3(1), 3–17.

Liu, Q., Schneider, F., Ma, L., Wenz, F., Herskind, C. (2013).术中瘤床照射模拟中测量的50kV X射线的相对生物效能(RBE)。International Journal of Radiation Oncology*Biology*Physics, 85(4), 1127–1133.

Minafra, L., & Bravatà, V. (2014).IORT治疗的细胞和分子反应。Translational Cancer Research, 3(1), 32–47.
Sologuren, I., Rodríguez-gallego, C., & Lara, P. C. (2014).高剂量放射治疗免疫作用：电离辐射对旁观者和延迟效应的发展启示。Transl Cancer Res, 3(1), 18–31.
Woolf, D. K., Williams, N. R., Bakshi, R., Madani, S. Y., Eaton, D. J., Fawcitt, S., … Keshtgar, M. (2014).乳腺癌放射治疗的生物剂量学：外照射与术中放疗的比较。SpringerPlus, 3, 329.

9。生活质量与美容效果

Coombs, N. J., Coombs, J. M., Vaidya, U. J., Singer, J., Bulsara, M., Tobias, J. S., … Vaidya, J. S. (2016).乳腺癌靶向术中放疗的环境和社会效益：从英国TARGIT-A试验中心和提供TARGIT IORT数据的两家英国NHS医院。BMJ Open, 6(5).

Corica, T., Joseph, D., Saunders, C., Bulsara, M., Nowak, A. K. (2014).早期乳腺癌术中放疗：医护人员选择方便还是风险？Radiation Oncology, 9(1), 1–9.

Corica, T., Nowak, A. K., Saunders, C. M., Bulsara, M., Taylor, M., Vaidya, J. S., … Joseph, D. J. (2016).早期乳腺癌术中放疗后的美容和乳腺相关的生活质量结果：TARGIT-A试验字研究。International Journal of Radiation Oncology*Biology*Physics, 96(1), 55–64.

Cardoso, M. J., Cardoso, J. S., Oliveira, H. P., Gouveia, P. (2016).乳腺癌保守治疗。美容效果– BCCT.core – 对乳腺癌保守治疗的美学效果客观评价软件：叙事评论。Computer Methods and Programs in Biomedicine, 126, 154–159.

Cracco, S., Semprini, G., Cattin, F., Gregoraci, G., Zeppieri, M., Isola, M., … Parodi, P. C. (2015).肿瘤乳腺手术后术中放疗对美容效果和并发症的影响。The Breast Journal, 21(3), 285–290

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013).乳腺癌靶向放疗后美容效果的客观评价：随机对照试验结果。Breast Cancer Research and Treatment, 140(3), 519–525.

Massa, M., Meszaros, P., Baldelli, I., Bisso, N., Franchelli, S. (2015).整型和保乳手术的审美评价：比较分析。Plast Reconstr Surg Glob Open, 3(3), e339.

Ng, J., Dai, T. (2016).放射治疗和异位效应：一个概念的时代到来。Annals of Translational Medicine, 4(6), 118–118.

Soror, T., Kovács, G., Kovács, Á., Seibold, N., Melchert, C., Baumann, K., … Stojanovic-Rundic, S. (2016).报告基于非标准化照片的乳房乳腺保守治疗之后的新目标方法：目标乳房大小。Brachytherapy, [Epub ahead of print].

Welzel, G., Hofmann, F., Blank, E., Kraus-Tiefenbacher, U., Hermann, B., Sütterlin, M., Wenz, F. (2010).使用低剂量的X射线进行乳腺癌保乳手术和术中放疗后的健康相关生活质量。Annals of Surgical Oncology, 17(S3), 359–367.

Yu, T., Eom, K. Y., Jang, N. Y., Kim, K. S., Koo, T. R., Kwon, J., … Kim, I. A. (2016).使用BCCT.core进行乳腺癌保乳治疗美容效果的客观测量。Cancer Research and Treatment, 48(2), 491–498.

10。IORT概览

Biggs, D. S., Thomson, E. S. (1996).手术放射治疗微型X线设备的辐射特性。The British Journal of Radiology, 69(822), 544–7.

Calvo, F. A. (2017).术中照射：精准医学促进癌症控制。Radiation Oncology, 12(1), 36.

Calvo, F. A., Sole, C. V, González, M. E., Tangco, E. D., López-Tarjuelo, J., Koubychine, I., … Ferrer, C. (2013).术中放疗的研究机会：未来十年2013 - 2023。Clinical and Translational Oncology, 15(9), 683–690.

Coles, C. E., Yarnold, J. R. (2016).加速部分乳腺照射：新标准？The Lancet, 387(10015), 201–202.

Debenham, B. J., Hu, K. S., Harrison, L. B. (2013).术中放疗的现状与展望。The Lancet Oncology, 14(11), e457–e464.

Eaton, D. J. (2015).电子近距离放射治疗——现状及未来发展方向。The British Journal of Radiology, 88(1049), 20150002.

Holmes, D. R. (2015).术中放疗治疗早期乳腺癌：已经成熟。The Breast Journal, 21(2), 181–184.

Mooney, H. (2014).NICE走在乳腺癌光子放射治疗前面。BMJ, 349(jul28 6), g4863–g4863.

Kalakota, K., Small, W. (2014).术中放疗技术与乳腺癌的选择。Expert Review of Medical Devices, 11(3), 265–73.

Paolo, V., De Lorenzi Francesca, Pietro, L., Mario, R., Umberto, V. (2016).在有植入体的妇女中乳腺癌肿瘤和手术治疗的当前趋势：发病率，诊断和治疗。Aesthetic Plastic Surgery, 40(2), 256–265.

Thariat, J., Hannoun-Levi, J.-M., Sun Myint, A., Vuong, T., Gérard, J.-P. (2012).放射治疗的过去、现在和未来。Nature Reviews Clinical Oncology, 10(1), 52–60.

Tobias, J. S., Vaidya, J. S., Keshtgar, M., D’Souza, D. P., Baum, M. (2004).早期乳腺癌放疗剂量降低：适形术中放疗的概念。The British Journal of Radiology, 77(916), 279–84.

11。临床应用指南

AGO.(2014)。原发性和转移性乳腺癌的诊断和治疗指南(版本.1).

Aetna.(2015)。Intraoperative Radiation Therapy (IORT).

DEGRO.(n.d.)。Leitlinie zur Weiterbildung zum Facharzt für Strahlentherapie.

Gnant, M., Harbeck, N., Thomssen, C. (2011).St. Gallen 2011:共识讨论综述。Breast Care, 6(2), 136–141.

Goldhirsch, A., Wood, W. C., Coates, A. S., Gelber, R. D., Thürlimann, B., Senn, H. J. (2011).亚型治疗乳腺癌多样性的策略：早期乳腺癌治疗方面的2011圣加仑国际专家共识亮点。Annals of Oncology, 22(8), 1736–1747.

NCCN.(2015)。NCCN Clinical Practice Guidelines in Oncology - Breast Cancer.

NCCN.(2016)。NCCN Clinical Practice Guidelines in Oncology - Colon Cancer.

NCCN.(2016)。NCCN Clinical Practice Guidelines in Oncology - Rectal Cancer.

Polgár, C., Limbergen, E. Van, Pötter, R., Kovács, G., Polo, A., Lyczek, J., … Strnad, V. (2010).保乳手术后加速部分乳腺照射(APBI)患者选择：集团Européen de Curiethérapie推荐——欧洲社会放射治疗及肿瘤(GEC-ESTRO) 乳腺癌工作组。Radiotherapy and Oncology, 94(3), 264–273.

Sedlmayer, F., Sautter-Bihl, M. L., Budach, W., Dunst, J., Fastner, G., Feyer, P., … Sauer, R. (2013).DEGRO实用指南：乳腺癌I期放射治疗：浸润性乳腺癌保乳治疗后的放射治疗。Strahlentherapie Und Onkologie, 189(10), 825–833.

Smith, B. D., Arthur, D. W., Buchholz, T. A., Haffty, B. G., Hahn, C. A., Hardenbergh, P. H., … Harris, J. R. (2009).美国放射肿瘤学会加速部分乳腺照射共识声明 (ASTRO)。International Journal of Radiation Oncology*Biology*Physics, 74(4), 987-1001.

12。临床试验

Institut du Cancer de Montpellier - Val d'Aurelle.术中放疗(IORT)和局部复发乳腺癌后的二次乳腺癌保乳术的可行性临床试验。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02386371.

Liao Ning.保留乳头乳房切除术后有乳腺导管原位癌的妇女的术中放疗。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02389686.

Liao Ning.治疗乳腺导管原位癌妇女的保乳术后的术中放疗。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02389673.

Loyola University.术中放疗联合椎体后凸成形术治疗脊柱转移瘤。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02480036.

Loyola University.低剂量术中辐射对可切除胰腺癌患者的一期研究。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年7月14日引用]。NLM 标识符:NCT02599662

Universitätsmedizin Mannheim.术中放疗新诊断的多形性胶质母细胞瘤的多中心III期随机临床试验 (INTRAGO II)。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02685605.

Universitätsmedizin Mannheim.INTRAGO-胶质母细胞瘤术中放疗 - I/II期研究。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02104882.

Universitätsmedizin Mannheim.椎体后凸成形术和椎体成形术(Kypho-IORT)与椎体转移瘤治疗EBRT 期间的术中放疗—— 一项随机前瞻性III期研究 ——。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年7月14日引用]。NLM 标识符:NCT02773966.

Universitätsmedizin Mannheim.患小乳腺癌的患者中进行的术中放疗(IORT) 的TARGIT-C(固结) 前瞻性IV期研究。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT02290782.

Universitätsmedizin Mannheim.术中靶向放疗与INTRABEAM-系统作为乳腺癌患者的高级推量—— 德国的质量控制注册表 (TARGIT BQR)。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT01440010.

University College, London.一项国际随机对照试验，比较有局部复发高风险的妇女乳腺癌切除术后，靶向术中放疗推量与常规外照射放疗推量。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT01792726.

University of California, San Francisco.美国术中靶向放疗 (TARGIT-US)IV期注册试验：乳腺癌保乳术后靶向放射治疗的注册表试验。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT01570998.

University of Dundee.采用光子放射治疗系统(PRS)进行术中放疗 (IORT)治疗直肠癌：I期临床试验。在:ClinicalTrials.gov [以太网]。Bethesda (MD):National Library of Medicine (US)。2000- [2016年9月6日引用]。NLM 标识符:NCT00910494.

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蔡司术中放疗案例

了解更多癌症以及使用术中放疗(IORT)治疗癌症的好处。了解蔡司放疗系统支持的肿瘤适应症，以及您的放疗环境将在蔡司术中放疗系统中得以优化。

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在这段视频中对组件和XRS的功能性进行了描述。术中放疗治疗期间 XRS内部如何工作。

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这段视频显示了通过术中放疗进行的乳腺癌保乳手术(BCS)并描述了治疗期间不同的工作流步骤。

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这段视频显示使用 Kypho-IORT 技术治疗脊柱转移瘤患者时不同的工作流步骤。

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